Trend Micro delisted its depository shares from the NASDAQ stock exchange in May. In March 2007, Trend Micro acquired freeware antispyware program HijackThis from its creator Merijn Bellekom for an undisclosed sum. Kelkea chief executive officer Dave Rand was retained by Trend Micro as its chief technologist for content security. Kelkea developed Mail Abuse Prevention System (MAPS) and IP filtering software that allowed internet service providers to block spam and phishing scams. In June 2005 Trend Micro acquired Kelkea, a San Jose, California-based developer of antispam software. Trend Micro had fully integrated InterMute's SpySubtract antispyware program into its antispyware product offerings by the end of that year. In May, Trend Micro acquired Braintree, Massachusetts-based antispyware company InterMute for $15 million. Chang retained his position as company chairman. Chen had most recently served as the company's chief technology officer since 1996 and before that executive vice president since the company's founding in October 1989. Company co-founder Eva Chen succeeded Chang as chief executive officer of Trend Micro in January 2005. In 2004, founding chief executive officer Steve Chang decided to split the responsibilities of CEO and chairman of the company. The company began trading on the United States-based NASDAQ stock exchange in July 1999. Trend Micro was listed on the Tokyo Stock Exchange in 1998 under the ticker 4704. In 1996 the two companies agreed to a two-year continuation of the agreement in which Trend was allowed to globally market the ServerProtect product under its own brand alongside Intel's LANDesk brand.

In 1993, Novell began bundling the product with its network operating system.

Intel paid royalties to Trend Micro for sales of LANDesk Virus Protect in the United States and Europe, while Trend paid royalties to Intel for sales in Asia. It then made an agreement with CPU maker Intel, under which it produced an anti-virus product for local area networks ( LANs) for sale under the Intel brand. In 1992, Trend Micro took over a Japanese software firm to form Trend Micro Devices and established headquarters in Japan. Shortly after establishing the company, its founders moved headquarters to Taipei. The company was established with proceeds from Steve Chang's previous sale of a copy protection dongle to a United States-based Rainbow Technologies. The company was founded in 1988 in Los Angeles by Steve Chang, his wife, Jenny Chang, and her sister, Eva Chen (陳怡樺).

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